Cohort Study Design

The Tennessee Alzheimer’s Project (TAP) cohort includes community-dwelling participants age 60-90, with cognition ranging from cognitively normal to MCI and dementia. Approximately, 20% of TAP participants identify as being part of an underrepresented group.  
 
At baseline, participants complete a physical and frailty examination, fasting blood draw, neuropsychological assessment, echocardiogram, and brain MRI. A subset undergo a lumbar puncture for cerebrospinal fluid collection and consent to postmortem brain donation. Participants will return annually to complete the full range of study components.
 
Please see Data Availability for subsequent epoch information. 
 
A portion of the data collected from the TAP cohort is part of the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. This data can be requested from NACC directly by visit https://naccdata.org/.