1. ADSP-PHC
  2. Data
  3. Data Availability

Overall and ADSP-Sequenced Data Availability

Section 1: Overall

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available cohort data that were included in the harmonization process.

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available longitudinal cohort data that were included in the harmonization process.

Section 2: ADSP

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for the available cohort data that were included in the harmonization process that are part of the Alzheimer’s Disease Sequencing Project (ADSP) and have a sequenced ADSP ID.


Note: The ADSP anticipates increased sample sizes in the sequencing of genomic data from underrepresented groups through investment in the ADSP Follow-Up Study (FUS) 2.0, which was launched in 2021 to expand the sample set in ADSP to represent more diverse populations. We expect the availability of these data to increase in the coming years and will be reflected in following ADSP-PHC freezes. Learn more about the ADSP FUS 2.0 here.


Chosen criteria

Section 1: Overall

To ensure the most thorough harmonization, domain teams harmonized all available cohort data. The table below reflects all participants included in harmonization.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
No Cognitive Impairment Mild Cognitive Impairment Alzheimer's Dementia No Diagnosis Provided Overall
Sex
Male 22,024 8,895 9,006 13,984 53,909
Female 39,212 9,704 11,595 14,837 75,348
Race*
Asian 949 378 232 318 1,877
Black or African American 7,742 2,742 2,224 1,410 14,118
White 44,434 14,049 15,850 12,603 86,936
Multiple/Other/Unknown 8,088 1,425 2,276 1,903 13,692
Ethnicity
Hispanic or Latino 10,349 2,309 3,738 2,733 19,129
Not Hispanic or Latino 50,365 16,227 16,128 13,015 95,735

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the fluid biomarker draw visit or the visit most proximal to death

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis
Baseline (PHC_Visit=1 or PHC_Visit=NA*) With Three Visits (PHC_Visit=3) With Five Visits (PHC_Visit=5) With Seven Visits (PHC_Visit=7)
Sex
Male 53,909 14,505 7,788 4,148
Female 75,348 21,975 12,575 7,112
Race*
Asian 1,877 436 238 133
Black or African American 14,118 5,014 2,773 1,569
White 86,936 28,000 16,168 9,105
Multiple/Other/Unknown 13,692 3,029 1,184 453
Ethnicity
Hispanic or Latino 19,129 4,012 1,573 682
Not Hispanic or Latino 95,735 31,575 18,276 10,274
Diagnosis
No Cognitive Impairment 61,239 21,384 12,813 7,321
Mild Cognitive Impairment 18,599 5,665 2,928 1,564
Alzheimer's Dementia 20,601 5,948 2,888 1,396
No Diagnosis Provided 28,821 3,483 1,734 979

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* The baseline column includes the first visit for every participant, where PHC_Visit = NA occurs when a participant has fluid biomarker and/or neuropathology data, but does not have any cognitive data
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the fluid biomarker draw visit or the visit more proximal to death

Section 2: ADSP

In accordance with data sharing policies, only those individuals who have been sequenced by the ADSP and thus have an ADSP ID are available via the NIAGADS DSS. The table below reflects ADSP participants included in the latest NIAGADS release.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
ADSP Case ADSP Control ADSP Diagnosis Not Provided Overall
Sex
Male 7,618 6,983 3,412 18,013
Female 12,100 8,716 5,236 26,052
Race*
Asian 90 100 84 274
Black or African American 3,115 1,243 877 5,235
White 13,274 11,222 7,397 31,893
Multiple/Other/Unknown 3,090 1,192 265 4,547
Ethnicity
Hispanic or Latino 3,437 1,781 845 6,063
Not Hispanic or Latino 15,946 11,723 7,753 35,422

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals