1. ADSP-PHC
  2. Data
  3. Data Availability

Overall and ADSP-Sequenced Data Availability

Section 1: Overall

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available cohort data that were included in the harmonization process.

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available longitudinal cohort data that were included in the harmonization process.

Section 2: ADSP

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for the available cohort data that were included in the harmonization process that are part of the Alzheimer’s Disease Sequencing Project (ADSP) and have a sequenced ADSP ID.


Note: The ADSP anticipates increased sample sizes in the sequencing of genomic data from underrepresented groups through investment in the ADSP Follow-Up Study (FUS) 2.0, which was launched in 2021 to expand the sample set in ADSP to represent more diverse populations. We expect the availability of these data to increase in the coming years and will be reflected in following ADSP-PHC freezes. Learn more about the ADSP FUS 2.0 here.


Chosen criteria

Section 1: Overall

To ensure the most thorough harmonization, domain teams harmonized all available cohort data. The table below reflects all participants included in harmonization.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
No Cognitive Impairment Mild Cognitive Impairment Alzheimer's Dementia No Diagnosis Provided Overall
Sex
Male 20,493 7,962 8,439 9,950 46,844
Female 36,829 9,015 11,231 10,451 67,526
Race*
Asian 1,599 550 374 163 2,686
Black or African American 7,751 2,923 2,249 931 13,854
White 40,461 12,528 14,964 6,444 74,397
Multiple/Other/Unknown 7,225 888 1,961 366 10,440
Ethnicity
Hispanic or Latino 12,664 2,671 3,818 821 19,974
Not Hispanic or Latino 43,647 14,131 14,935 6,927 79,640

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the fluid biomarker draw visit or the visit most proximal to death

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis
Baseline (PHC_Visit=1 or PHC_Visit=NA*) With Three Visits (PHC_Visit=3) With Five Visits (PHC_Visit=5) With Seven Visits (PHC_Visit=7)
Sex
Male 46,844 17,531 9,755 5,480
Female 67,526 26,383 15,593 9,225
Race*
Asian 2,686 1,210 680 251
Black or African American 13,854 5,616 3,109 1,760
White 74,397 34,620 20,685 12,353
Multiple/Other/Unknown 10,440 2,240 821 328
Ethnicity
Hispanic or Latino 19,974 5,088 2,269 990
Not Hispanic or Latino 79,640 37,693 22,525 13,392
Diagnosis
No Cognitive Impairment 57,322 24,754 15,077 8,779
Mild Cognitive Impairment 16,977 6,607 3,397 1,807
Alzheimer's Dementia 19,670 8,398 4,044 1,959
No Diagnosis Provided 20,401 4,155 2,830 2,160

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* The baseline column includes the first visit for every participant, where PHC_Visit = NA occurs when a participant has fluid biomarker and/or neuropathology data, but does not have any cognitive data
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the fluid biomarker draw visit or the visit more proximal to death

Section 2: ADSP

In accordance with data sharing policies, only those individuals who have been sequenced by the ADSP and thus have an ADSP ID are available via the NIAGADS DSS. The table below reflects ADSP participants included in the latest NIAGADS release.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
ADSP Case ADSP Control ADSP Diagnosis Not Provided Overall
Sex
Male 6,906 4,207 3,669 14,782
Female 11,788 6,013 5,135 22,936
Race*
Asian 467 223 155 845
Black or African American 2,635 1,086 1,205 4,926
White 12,090 7,542 4,803 24,435
Multiple/Other/Unknown 3,368 1,287 539 5,194
Ethnicity
Hispanic or Latino 5,409 2,397 1,895 9,701
Not Hispanic or Latino 12,924 7,481 4,770 25,175

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, Asian, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals