1. Data
  2. Data Availability

Overall and ADSP-Sequenced Data Availability

Section 1: Overall

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available cohort data that were included in the harmonization process.

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for all available longitudinal cohort data that were included in the harmonization process.

Section 2: ADSP

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis

This table provides sample size and demographic information for the available cohort data that were included in the harmonization process that are part of the Alzheimer’s Disease Sequencing Project (ADSP) and have a sequenced ADSP ID.


Note: The ADSP anticipates increased sample sizes in the sequencing of genomic data from underrepresented groups through investment in the ADSP Follow-Up Study (FUS) 2.0, which was launched in 2021 to expand the sample set in ADSP to represent more diverse populations. We expect the availability of these data to increase in the coming years and will be reflected in following ADSP-PHC freezes. Learn more about the ADSP FUS 2.0 here.


Chosen criteria

Section 1: Overall

To ensure the most thorough harmonization, domain teams harmonized all available cohort data. The table below reflects all participants included in harmonization.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
No Cognitive Impairment Mild Cognitive Impairment Alzheimer's Dementia Non-Alzheimer's Dementia Other Cognitive Diagnosis No Diagnosis Provided Overall
Sex
Male 21,348 8,938 8,826 2,567 1,077 7,669 50,425
Female 38,340 10,371 11,820 1,801 1,507 9,090 72,929
Race*
Asian 1,636 567 365 100 67 151 2,886
Black or African American 8,428 3,258 2,406 280 628 618 15,618
White 42,806 13,530 15,399 3,788 1,715 3,372 80,610
Multiple/Other/Unknown 6,818 1,954 2,476 200 174 154 11,776
Ethnicity
Hispanic or Latino 11,690 4,214 4,471 445 368 454 21,642
Not Hispanic or Latino 46,979 14,934 15,247 3,847 2,186 3,584 86,777

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the visits from the selected criteria

Table 2: Longitudinal sample size by demographics characteristics and clinical diagnosis
Baseline (PHC_Visit=1) With Three Visits (PHC_Visit=3) With Five Visits (PHC_Visit=5) With Ten or More Visits (PHC_Visit=10)
Sex
Male 50,425 21,543 12,747 3,486
Female 72,929 32,226 19,768 6,125
Race*
Asian 2,886 1,511 904 170
Black or African American 15,618 6,822 3,862 1,081
White 80,610 42,388 26,578 8,231
Multiple/Other/Unknown 11,776 3,048 1,171 129
Ethnicity
Hispanic or Latino 21,642 6,426 2,827 377
Not Hispanic or Latino 86,777 46,072 29,024 9,019
Diagnosis
No Cognitive Impairment 59,688 27,697 17,361 4,935
Mild Cognitive Impairment 19,309 8,277 4,528 1,179
Alzheimer's Dementia 20,646 10,443 5,708 1,182
Non-Alzheimer's Dementia 4,368 1,948 901 180
Other Cognitive Diagnosis 2,584 1,532 1,129 351
No Diagnosis Provided 16,759 3,872 2,888 1,784

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals
* The clinical diagnostic columns represents diagnosis at first available visit for each participant, which may or may not correspond to the visits from the selected criteria

Section 2: ADSP

In accordance with data sharing policies, only those individuals who have been sequenced by the ADSP and thus have an ADSP ID are available via the NIAGADS DSS. The table below reflects ADSP participants included in the latest NIAGADS release.

Table 1: Baseline sample size by demographics characteristics and clinical diagnosis
ADSP Case ADSP Control ADSP Diagnosis Not Provided Overall
Sex
Male 7,223 4,453 3,744 15,420
Female 12,256 6,412 5,187 23,855
Race*
Asian 461 223 155 839
Black or African American 2,626 1,114 1,205 4,945
White 12,834 8,113 4,922 25,869
Multiple/Other/Unknown 3,558 1,415 549 5,522
Ethnicity
Hispanic or Latino 5,433 2,469 1,901 9,803
Not Hispanic or Latino 13,681 7,990 4,886 26,557

* Multiple/Other/Unknown Race category includes: American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander
* Sample size < 10 is written when at least one value in the section has a sample size of less than 10 individuals